abstract：:The forkhead transcription factor FOXM1 has a key role in DNA damage response, and its deregulated overexpression is associated with genotoxic drug resistance in breast cancer. However, little is known about the posttranslational mechanisms by which FOXM1 expression is regulated by genotoxic agents and how they are de...

journal_title：Oncogene

authors： Karunarathna U,Kongsema M,Zona S,Gong C,Cabrera E,Gomes AR,Man EP,Khongkow P,Tsang JW,Khoo US,Medema RH,Freire R,Lam EW

更新日期：2016-03-17 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT), marked by the dissolution of cell-cell junctions, loss of cell polarity and increased cell motility, is one of the essential steps for prostate cancer metastasis. However, the underlying mechanism has not been fully explored. We report in this study that Shp2 is upregulated ...

journal_title：Oncogene

authors： Zhang K,Zhao H,Ji Z,Zhang C,Zhou P,Wang L,Chen Q,Wang J,Zhang P,Chen Z,Zhu HH,Gao WQ

更新日期：2016-03-10 00:00:00

abstract：:Acquired therapeutic resistance is the major drawback to effective systemic therapies for cancers. Aggressive triple-negative breast cancers (TNBC) develop resistance to chemotherapies rapidly, whereas the underlying mechanisms are not completely understood. Here we show that genotoxic treatments significantly increas...

journal_title：Oncogene

authors： Niu J,Xue A,Chi Y,Xue J,Wang W,Zhao Z,Fan M,Yang CH,Shao ZM,Pfeffer LM,Wu J,Wu ZH

更新日期：2016-03-10 00:00:00

abstract：:Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor in haematological ma...

journal_title：Oncogene

authors： Hawkins ED,Oliaro J,Ramsbottom KM,Newbold A,Humbert PO,Johnstone RW,Russell SM

更新日期：2016-03-03 00:00:00

abstract：:Lung adenocarcinomas, like other cancers, develop through the accumulation of epigenetic and genetic alterations. Numerous studies have shown that K-RAS mutation is among the most important early events in carcinogenesis of the lung. However, it is also well established that growth-stimulating signals feed back into g...

journal_title：Oncogene

authors： Lee YS,Bae SC

更新日期：2016-02-18 00:00:00

abstract：:Reovirus is a naturally oncolytic virus that preferentially replicates in Ras-transformed cells and is currently undergoing clinical trials as a cancer therapeutic. Ras transformation promotes reovirus oncolysis by enhancing virion disassembly during entry, viral progeny production, and virus release through apoptosis...

journal_title：Oncogene

authors： Garant KA,Shmulevitz M,Pan L,Daigle RM,Ahn DG,Gujar SA,Lee PW

更新日期：2016-02-11 00:00:00

abstract：:Cells are under constant attack from genotoxins and rely on a multifaceted DNA damage response (DDR) network to maintain genomic integrity. Central to the DDR are the ATM and ATR kinases, which respond primarily to double-strand DNA breaks (DSBs) and replication stress, respectively. Optimal ATR signaling requires the...

journal_title：Oncogene

authors： Balmus G,Lim PX,Oswald A,Hume KR,Cassano A,Pierre J,Hill A,Huang W,August A,Stokol T,Southard T,Weiss RS

更新日期：2016-02-04 00:00:00

abstract：:Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The disease carries a high prevalence of activating mutations in MyD88 (91%) and CXCR4 (28%). Because signaling through these pathways leads to Bcl-xL induction, we ex...

journal_title：Oncogene

authors： Gaudette BT,Dwivedi B,Chitta KS,Poulain S,Powell D,Vertino P,Leleu X,Lonial S,Chanan-Khan AA,Kowalski J,Boise LH

更新日期：2016-01-28 00:00:00

abstract：:Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosph...

journal_title：Oncogene

authors： Wang W,Liao P,Shen M,Chen T,Chen Y,Li Y,Lin X,Ge X,Wang P

更新日期：2016-01-28 00:00:00

abstract：:The osteogenic transcription factor, Runx2, is abnormally expressed in prostate cancer (PCa) and associated with metastatic disease. During bone development, Runx2 is activated by signals known to be hyperactive in PCa including the RAS/MAP kinase pathway, which phosphorylates Runx2 on multiple serine residues includi...

journal_title：Oncogene

authors： Ge C,Zhao G,Li Y,Li H,Zhao X,Pannone G,Bufo P,Santoro A,Sanguedolce F,Tortorella S,Mattoni M,Papagerakis S,Keller ET,Franceschi RT

更新日期：2016-01-21 00:00:00

abstract：:The occurrence of peritoneal carcinomatosis is a major cause of treatment failure in colorectal cancer and is considered incurable. However, new therapeutic approaches have been proposed, including cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Although HIPEC has been effective ...

journal_title：Oncogene

authors： Zunino B,Rubio-Patiño C,Villa E,Meynet O,Proics E,Cornille A,Pommier S,Mondragón L,Chiche J,Bereder JM,Carles M,Ricci JE

更新日期：2016-01-14 00:00:00

abstract：:Currently, trastuzumab resistance is a major clinical problem in the treatment of Her2-overexpressing breast cancer. The underlying molecular mechanisms are not fully understood. Our previous study demonstrates that β2-adrenergic receptor (β2-AR) and Her2 comprise a positive feedback loop in human breast cancer cells ...

journal_title：Oncogene

authors： Liu D,Yang Z,Wang T,Yang Z,Chen H,Hu Y,Hu C,Guo L,Deng Q,Liu Y,Yu M,Shi M,Du N,Guo N

更新日期：2016-01-07 00:00:00

abstract：:TFAP2C/AP-2γ influences development of the mammary gland and regulates patterns of gene expression in luminal and HER2-amplified breast cancer. The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to cancer progression remain poorly understood. To gain greater insight into oncogenic mechanisms r...

journal_title：Oncogene

authors： Park JM,Wu T,Cyr AR,Woodfield GW,De Andrade JP,Spanheimer PM,Li T,Sugg SL,Lal G,Domann FE,Zhang W,Weigel RJ

更新日期：2015-12-10 00:00:00

abstract：:Radiation therapy (RT) is useful for selectively killing cancer cells. However, because high levels of ionizing radiation (IR) are toxic to normal cells, RT cannot be applied repeatedly to cancer patients. Therefore, novel chemicals that enhance the efficacy of chemoradiotherapy (CRT) would be valuable. Here, we repor...

journal_title：Oncogene

authors： Ohno S,Naito Y,Mukai S,Yabuta N,Nojima H

更新日期：2015-12-03 00:00:00

abstract：:Recent explosive advances in next-generation sequencing technology and computational approaches to massive data enable us to analyze a number of cancer genome profiles by whole-genome sequencing (WGS). To explore cancer genomic alterations and their diversity comprehensively, global and local cancer genome-sequencing ...

journal_title：Oncogene

authors： Nakagawa H,Wardell CP,Furuta M,Taniguchi H,Fujimoto A

更新日期：2015-12-03 00:00:00

abstract：:Suppressor of cytokine signaling 1 (SOCS1) is considered as a tumor suppressor protein in hepatocellular carcinoma (HCC), but the underlying mechanisms remain unclear. Previously, we have shown that SOCS1-deficient hepatocytes displayed increased responsiveness to hepatocyte growth factor (HGF) due to enhanced signali...

journal_title：Oncogene

authors： Gui Y,Yeganeh M,Donates YC,Tobelaim WS,Chababi W,Mayhue M,Yoshimura A,Ramanathan S,Saucier C,Ilangumaran S

更新日期：2015-11-12 00:00:00

abstract：:Cancer cells harboring oncogenic BRaf mutants, but not oncogenic KRas mutants, are sensitive to MEK inhibitors (MEKi). The mechanism underlying the intrinsic resistance to MEKi in KRas-mutant cells is under intensive investigation. Here, we pursued this mechanism by live imaging of extracellular signal-regulated kinas...

journal_title：Oncogene

authors： Komatsu N,Fujita Y,Matsuda M,Aoki K

更新日期：2015-11-05 00:00:00

abstract：:Malignant tumors are exemplified by excessive proliferation and aggressive migration/invasion contributing to increased mortality of cancer patients. Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung cancer malignancy. The mechanism underlying an elevated MMP9 expression is not clearly de...

journal_title：Oncogene

authors： Cheng X,Yang Y,Fan Z,Yu L,Bai H,Zhou B,Wu X,Xu H,Fang M,Shen A,Chen Q,Xu Y

更新日期：2015-10-29 00:00:00

abstract：:Stimulator of interferon genes (STING) is a cellular sensor that controls cytosolic DNA-activated innate immune signaling. We have previously demonstrated that STING-deficient mice are resistant to carcinogen-induced skin cancer, similar to myeloid differentiation primary response gene 88 (MyD88) deficient mice, since...

journal_title：Oncogene

authors： Ahn J,Konno H,Barber GN

更新日期：2015-10-08 00:00:00

abstract：:Oncolytic adenoviruses, such as Delta-24-RGD (Δ24RGD), are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Δ24RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular mechanisms unde...

journal_title：Oncogene

authors： Klein SR,Piya S,Lu Z,Xia Y,Alonso MM,White EJ,Wei J,Gomez-Manzano C,Jiang H,Fueyo J

更新日期：2015-10-08 00:00:00

abstract：:p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) ...

journal_title：Oncogene

authors： Zhao D,Besser AH,Wander SA,Sun J,Zhou W,Wang B,Ince T,Durante MA,Guo W,Mills G,Theodorescu D,Slingerland J

更新日期：2015-10-01 00:00:00

abstract：:There is increasing evidence that mast cells (MCs) and their mediators are involved in the remodeling of the tumor microenvironment and promote tumor growth, angiogenesis and metastasis. We have found that an increased density of MCs in thyroid cancer (TC) correlates with enhanced invasiveness. However, the MC-derived...

journal_title：Oncogene

authors： Visciano C,Liotti F,Prevete N,Cali' G,Franco R,Collina F,de Paulis A,Marone G,Santoro M,Melillo RM

更新日期：2015-10-01 00:00:00

abstract：:Detachment of non-malignant epithelial cells from the extracellular matrix causes their apoptosis, a phenomenon called anoikis. By contrast, carcinoma cells are anoikis-resistant, and this resistance is thought to be critical for tumor progression. Many oncogenes trigger not only anti- but also pr-apoptotic signals. T...

journal_title：Oncogene

authors： Yoo BH,Masson O,Li Y,Khan IA,Gowda PS,Rosen KV

更新日期：2015-09-17 00:00:00

abstract：:Post-translational acetylation of lysines is most extensively studied in histones, but this modification is also found in many other proteins and is implicated in a wide range of biological processes in both the cell nucleus and the cytoplasm. Like phosphorylation, acetylation patterns and levels are often altered in ...

journal_title：Oncogene

authors： Farria A,Li W,Dent SY

更新日期：2015-09-17 00:00:00

abstract：:Although increasing evidence indicated that the deregulation of microRNAs (miRNAs) contributes to tumorigenesis and invasion, little is known about the role of miR-637 in human gliomas. In the present study, we found that the expression level of miR-637 was significantly reduced in clinical glioma tissues compared wit...

journal_title：Oncogene

authors： Que T,Song Y,Liu Z,Zheng S,Long H,Li Z,Liu Y,Wang G,Liu Y,Zhou J,Zhang X,Fang W,Qi S

更新日期：2015-09-17 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and the mechanisms behind it remain unclear. Thioredoxin domain-containing protein 5 (TXNDC5) is involved in protein folding and chaperone activity, and its overexpression has been reported in multiple malignancies. In the current stu...

journal_title：Oncogene

authors： Wang L,Song G,Chang X,Tan W,Pan J,Zhu X,Liu Z,Qi M,Yu J,Han B

更新日期：2015-09-03 00:00:00

abstract：:Nuclear Foxc2 is a transcriptional regulator of mesenchymal transformation during developmental epithelial-mesenchymal transition (EMT) and has been associated with EMT in malignant epithelia. Our laboratory has shown that in normal epithelial cells Foxc2 is maintained in the cytoplasm where it promotes an epithelial ...

journal_title：Oncogene

authors： Golden D,Cantley LG

更新日期：2015-09-03 00:00:00

abstract：:Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...

journal_title：Oncogene

authors： Wang P,Chen SH,Hung WC,Paul C,Zhu F,Guan PP,Huso DL,Kontrogianni-Konstantopoulos A,Konstantopoulos K

更新日期：2015-08-27 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded Latent Membrane Protein 2A (LMP2A) is an EBV latency-associated protein regularly expressed in nasopharyngeal carcinoma (NPC). In B cells, LMP2A activity resembles that of a constitutively activated antigen receptor, which recruits the Syk tyrosine kinase to activate a set of downstrea...

journal_title：Oncogene

authors： Zhou X,Matskova L,Rathje LS,Xiao X,Gish G,Werner M,Ignatyev I,Yu N,Zhao W,Tian F,Hou B,Zhang Z,Pawson T,Chen F,Ernberg I

更新日期：2015-08-20 00:00:00

abstract：:Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional respon...

journal_title：Oncogene

authors： Choudhry H,Albukhari A,Morotti M,Haider S,Moralli D,Smythies J,Schödel J,Green CM,Camps C,Buffa F,Ratcliffe P,Ragoussis J,Harris AL,Mole DR

更新日期：2015-08-20 00:00:00

abstract：:Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (...

journal_title：Oncogene

authors： Schoeneberger H,Belz K,Schenk B,Fulda S

更新日期：2015-07-30 00:00:00

abstract：:Disruption of Apc (adenomatous polyposis coli) within hepatocytes activates Wnt signalling, perturbs differentiation and ultimately leads to neoplasia. Apc negatively regulates Wnt signalling but is also involved in organizing the cytoskeleton and may have a role in chromosome segregation. In vitro studies have implic...

journal_title：Oncogene

authors： Méniel V,Megges M,Young MA,Cole A,Sansom OJ,Clarke AR

更新日期：2015-07-30 00:00:00

abstract：:Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen. Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is most often increased in tumour cells. HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-...

journal_title：Oncogene

authors： Lincet H,Icard P

更新日期：2015-07-01 00:00:00

abstract：:Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epit...

journal_title：Oncogene

authors： Dembowy J,Adissu HA,Liu JC,Zacksenhaus E,Woodgett JR

更新日期：2015-07-01 00:00:00

abstract：:Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to rep...

journal_title：Oncogene

authors： Kasinski AL,Kelnar K,Stahlhut C,Orellana E,Zhao J,Shimer E,Dysart S,Chen X,Bader AG,Slack FJ

更新日期：2015-07-01 00:00:00

abstract：:Glioblastoma is the most common and lethal primary malignant brain tumor in adults. The tumor suppressor gene PTEN is deleted, mutated or hypermethylated in more than 60% of glioblastoma cases resulting in hyperactivation of the phosphoinositide 3-kinase pathway, which leads to sustained PI(3,4,5)P3 signaling, and the...

journal_title：Oncogene

authors： Davies EM,Kong AM,Tan A,Gurung R,Sriratana A,Bukczynska PE,Ooms LM,McLean CA,Tiganis T,Mitchell CA

更新日期：2015-07-01 00:00:00

abstract：:The biological outcome of TMPRSS2:ERG chromosomal translocations in prostate cancer (PC) remains poorly understood. To address this, we compared the transcriptional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a TMPRSS2:ERG-positive PC cell line. This reveals that ERG re...

journal_title：Oncogene

authors： Mounir Z,Lin F,Lin VG,Korn JM,Yu Y,Valdez R,Aina OH,Buchwalter G,Jaffe AB,Korpal M,Zhu P,Brown M,Cardiff RD,Rocnik JL,Yang Y,Pagliarini R

更新日期：2015-07-01 00:00:00

abstract：:The matricellular protein CCN5/WISP-2 represents a promising target in triple-negative breast cancer (TNBC) because treatment or induced activation of CCN5 in TNBC cells promotes cell growth arrest at the G0/G1 phase, reduces cell proliferation and delays tumor growth in the xenograft model. Our studies found that the...

journal_title：Oncogene

authors： Haque I,Banerjee S,De A,Maity G,Sarkar S,Majumdar M,Jha SS,McGragor D,Banerjee SK

更新日期：2015-06-11 00:00:00

abstract：:Despite the recent success of MAPK signaling-targeted drugs in melanoma, the majority of patients with metastatic melanoma still undergo disease progression after initial tumor shrinkage indicating gradually developing therapy resistance. This review will give an overview on currently suggested concepts of resistance ...

journal_title：Oncogene

authors： Roesch A

更新日期：2015-06-04 00:00:00

abstract：:Checkpoint kinase 1 (CHK1) is a key component of the ATR (ataxia telangiectasia-mutated and Rad3-related)-dependent DNA damage response pathway that protect cells from replication stress, a cell intrinsic phenomenon enhanced by oncogenic transformation. Here, we show that CHK1 is overexpressed and hyperactivated in T-...

journal_title：Oncogene

authors： Sarmento LM,Póvoa V,Nascimento R,Real G,Antunes I,Martins LR,Moita C,Alves PM,Abecasis M,Moita LF,Parkhouse RM,Meijerink JP,Barata JT

更新日期：2015-06-04 00:00:00